Throughput, flexibility, and cost are the top three considerations when choosing a plate reader. In pharmaceutical research, for example, throughput might be the top criterion. Regarding flexibility, a single-mode instrument, such as an absorbance reader for ELISAs, may fit the bill (some can capture a full UV-VIS spectrum from 220 to 1000 nm), but a multimode reader that offers additional capabilities such as fluorescence may offset the additional cost outlay. Integrated software, type of plates accepted, and built-ins like incubators and plate shakers are additional considerations.
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